Σταδιοποίηση σε Ca Σιελογόνων Αδένων

 

Ca Σιελογόνου Αδένα

AJCC Stages

Stages

T

N

M

I

T1

N0

M0

II

T2

N0

M0

III

T3

N0

M0

T1

N1

M0

T2

N1

M0

T3

N1

M0

IVA

T4a

N0

M0

T4a

N1

M0

T1

N2

M0

T2

N2

M0

T3

N2

M0

T4a

N2

M0

IVB

T4b

Any N

M0

Any T

N3

M0

IVC

Any T

Any N

M1

(T) Primary Tumor

TX

Primary tumor cannot be assessed

T0

No evidence of primary tumor

T1

Tumor ≤ 2 cm in greatest dimension without extraparenchymal extension*

T2

Tumor > 2 cm but ≤ 4 cm in greatest dimension without extraparenchymal extension*

T3

Tumor > 4 cm &/or tumor having extraparenchymal extension*

T4a

Moderately advanced disease: Tumor invades skin, mandible, ear canal, &/or facial nerve

T4b

Very advanced disease: Tumor invades skull base &/or pterygoid plates &/or encases carotid artery

*Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes.

(N) Regional Lymph Nodes

NX

Regional lymph nodes cannot be assessed

N0

No regional lymph node metastasis

N1

Metastasis in a single ipsilateral lymph node, ≤ 3 cm in greatest dimension

N2

Metastasis in a single ipsilateral lymph node, > 3 cm but ≤ 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none > 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none > 6 cm in greatest dimension

N2a

Metastasis in a single ipsilateral lymph node, > 3 cm but ≤ 6 cm in greatest dimension

N2b

Metastasis in multiple ipsilateral lymph nodes, none > 6 cm in greatest dimension

N2c

Metastasis in bilateral or contralateral lymph nodes, none > 6 cm in greatest dimension

N3

Metastasis in a lymph node, > 6 cm in greatest dimension

(M) Distant Metastasis

M0

No distant metastasis

M1

Distant metastasis

Χαρακτηριστικά Επέκτασης

Regional nodal spread from salivary gland carcinoma is relatively rare compared to other mucosal squamous cell carcinomas of head and neck

Lymphatic spread varies according to histology and size of primary tumor

  • Low-grade tumors rarely metastasize
  • High-grade tumors have substantially higher risk of regional nodal spread

Regional nodal spread is orderly

  • Intraglandular nodes
  • Adjacent (periparotid, submandibular) nodes
  • Upper and midjugular nodes
  • Retropharyngeal nodes

Most nodal metastases will be apparent on initial physical examination, but bilateral spread is rare

Distant metastasis is most commonly to

  • Lungs
  • Brain
  • Bone

Adenoid cystic carcinoma

  • High incidence of distant metastasis (lung, bone)
  • Perineural spread also characteristic

Mucoepidermoid carcinoma

  • Lymph node metastases common

Κατηγοριοποίηση (Ιστολογικοί Τύποι)

WHO histological classification for tumors of salivary glands

  • Malignant epithelial tumors
    • Acinic cell carcinoma (12%)
    • Mucoepidermoid carcinoma
      • Low-grade mucoepidermoid (25%)
      • High-grade mucoepidermoid (20%)
    • Adenoid cystic carcinoma (6-15%)
    • Polymorphous low-grade adenocarcinoma
    • Epithelial-myoepithelial carcinoma
    • Clear cell carcinoma, not otherwise specified (NOS)
    • Basal cell adenocarcinoma
    • Sebaceous carcinoma
    • Sebaceous lymphadenocarcinoma
    • Cystadenocarcinoma
    • Low-grade cribriform cystadenocarcinoma
    • Mucinous adenocarcinoma
    • Oncocytic carcinoma
    • Salivary duct carcinoma
    • Adenocarcinoma, NOS
    • Myoepithelial carcinoma
    • Carcinoma ex pleomorphic adenoma (9%)
    • Carcinosarcoma
    • Metastasizing pleomorphic adenoma
    • Squamous cell carcinoma (1-7%)
    • Small cell carcinoma
  • Large cell carcinoma
  • Lymphoepithelial carcinoma
  • Sialoblastoma
  • Benign epithelial tumors
    • Pleomorphic adenoma (a.k.a. benign mixed)
    • Myoepithelioma
    • Basal cell adenoma
    • Warthin tumor
    • Oncocytoma
    • Canalicular adenoma
    • Sebaceous adenoma
    • Lymphadenoma
      • Sebaceous
      • Nonsebaceous
    • Ductal papillomas
      • Inverted ductal papilloma
      • Intraductal papilloma
      • Sialadenoma papilliferum
    • Cystadenoma
  • Soft tissue tumors
    • Hemangioma
  • Hematolymphoid tumors
    • Hodgkin lymphoma
    • Diffuse large B-cell lymphoma
    • Extranodal marginal zone B-cell lymphoma
  • Secondary tumors