Σταδιοποίηση σε Ca Μήτρας

 

Ca Σώματος Μήτρας

AJCC Stages – Ca Μήτρας*

Stages

T

N

M

0

Tis

N0

M0

I

T1

N0

M0

IA

T1a

N0

M0

IB

T1b

N0

M0

II

T2

N0

M0

III

T3

N0

M0

IIIA

T3a

N0

M0

IIIB

T3b

N0

M0

IIIC1

T1-T3

N1

M0

IIIC2

T1-T3

N2

M0

IVA

T4

Any N

M0

IVB

Any T

Any N

M1

*Carcinosarcomas should be staged as carcinoma.

(T) Primary Tumor

TNM

FIGO

Definitions

TX

 

Primary tumor cannot be assessed

T0

 

No evidence of primary tumor

Tis¹

 

Carcinoma in situ (preinvasive carcinoma)

T1

I

Tumor confined to corpus uteri

T1a

IA

Tumor limited to endometrium or invades < 1/2 of the myometrium

T1b

IB

Tumor invades ≥ 1/2 of the myometrium

T2

II

Tumor invades stromal connective tissue of the cervix but does not extend beyond uterus²

T3a

IIIA

Tumor invades serosa &/or adnexa (direct extension or metastasis)

T3b

IIIB

Vaginal involvement (direct extension or metastasis) or parametrial involvement

T4

IVA

Tumor invades bladder mucosa &/or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4)

¹FIGO no longer includes stage 0 (Tis). 
²Endocervical glandular involvement only should be considered as stage I and not as stage II.

(N) Regional Lymph Nodes

NX

 

Regional lymph nodes cannot be assessed

N0

 

No regional lymph node metastasis

N1

IIIC1

Regional lymph node metastasis to pelvic lymph nodes

N2

IIIC2

Regional lymph node metastasis to paraaortic lymph nodes, with or without positive pelvic lymph nodes

(M) Distant Metastasis

M0

 

No distant metastasis

M1

IVB

Distant metastasis (includes metastasis to inguinal lymph nodes intraperitoneal disease, or lung, liver, or bone; excludes metastasis to paraaortic lymph nodes, vagina, pelvic serosa, or adnexa)

Χαρακτηριστικά Επέκτασης

Direct extension

  • Most common

Lymphatic spread

  • Common nodes include
    • Pelvic (N1)
    • Paraaortic (N2)
    • Inguinal nodes (less common)
  • Hematogenous spread
    • Lungs
    • Liver
    • Bone
    • Skin
    • Brain (uncommon)
  • Peritoneal spread
  • Intraperitoneal implants
  • Common in papillary serous Ca

Κατηγοριοποίηση (Ιστολογικοί Τύποι)

Primary malignant tumors (WHO classification)

  • Endometrial carcinoma
    • Endometrioid adenocarcinoma
      • Several forms
    • Mucinous adenocarcinoma
    • Serous adenocarcinoma
    • Clear cell adenocarcinoma
    • Mixed cell adenocarcinoma
    • Squamous cell carcinoma
    • Transitional cell carcinoma
    • Small cell carcinoma
    • Others
  • Mesenchymal tumors
    • Endometrial stromal and related tumors
      • Endometrial stromal sarcoma, low grade
      • Endometrial stromal nodule
      • Undifferentiated endometrial sarcoma
    • Smooth muscle tumors
      • Leiomyosarcoma (epithelioid and myxoid variants)
      • Smooth muscle tumor of uncertain malignant potential
      • Leiomyoma, not otherwise specified
    • Miscellaneous mesenchymal tumors
  • Mixed epithelial and mesenchymal tumors
    • Carcinosarcoma
    • Adenosarcoma
    • Carcinofibroma
    • Adenofibroma
    • Adenomyoma
  • Gestational trophoblastic disease
    • Trophoblastic neoplasms
      • Choriocarcinoma
      • Placental site trophoblastic tumor
      • Epithelioid trophoblastic tumor
    • Molar pregnancies
      • Hydatiform mole
    • Nonneoplastic
      • Nonmolar trophoblastic lesions
  • Miscellaneous tumors
    • Sex cord-like tumors
    • Neuroectodermal tumors
    • Melanotic paraganglioma
    • Tumors of germ cell type
    • Others
  • Lymphoid and hematopoietic tumors
    • Malignant lymphoma
    • Leukemia

 

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